Strong Antagonistic Activity Of Isoprenaline Against Propranolol Induced Cardiovascular Depression

Rats anesthetized with pentobarbital and ventilated artificially were intoxicated with 1

mg/kg X min propranolol i.v. After 30 min heart rate, mean arterial blood pressure

and peripheral resistance had dropped by about 50% and cardiac output by about 25%

and were stable for up to 120 min. Isoprenaline proved to be the best antidote for the

treatment of propranolol intoxication antagonizing the bradycardia by 76% and the

hypotension completely.